CT-proAVP (Copeptin)*
To easily measure vasopressin
Arginine vasopressin (AVP) is a key hormone in the human body. Vasopressin is released from the neurohypophysis into the bloodstream in order to promote water conservation by the kidney and thereby contributes to the regulation of osmotic and cardiovascular homeostasis. Despite the clinical relevance of AVP in maintaining fluid balance and vascular tone, measurement of mature AVP is difficult and subject to preanalytical errors. Recently, copeptin, a 39-amino acid glycopeptide that comprises the C-terminal part of the AVP precursor (CT-proAVP), was found to be a stable and sensitive surrogate marker for AVP release, analogous to C-peptide for insulin.
Copeptin measurement has been shown in published studies to be useful in various clinical indications, including the diagnosis of diabetes insipidus and the monitoring of sepsis and cardiovascular diseases such as acute myocardial infarction and congestive heart failure.
For more information on copeptin, please call us or send a request to clinical.services@brahms-usa.com.
*CT-proAVP is currently available in the US as Research Use Only.